HUMAN COMPLEMENT ACTIVATION BY SELF-ASSOCIATED IgG RHEUMATOID FACTORS
نویسندگان
چکیده
منابع مشابه
The molecular basis of self-association of antibodies to IgG (rheumatoid factors) in rheumatoid arthritis.
The serum and synovial fluid of many patients with rheumatoid arthritis contain immune complexes composed of immunoglobulin G (IgG). In this study such complexes from one patient are shown to be formed by self-association of IgG-antibodies to IgG (IgG-rheumatoid factors), so that each molecule serves as an antibody as well as an antigen. All F(ab')(2) and Fab' fragments derived from these compl...
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The capacity for fixation and activation of hemolytic complement by polyclonal IgM rheumatoid factors (RF) isolated from sera of patients with rheumatoid arthritis and monoclonal IgM-RF isolated from the cryoprecipitates of patients with IgM-IgG mixed cryoglobulinemia was examined. RF mixed with aggregated, reduced, and alkylated human IgG (Agg-R/A-IgG) in the fluid phase failed to significantl...
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OBJECTIVES Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterised by synovitis and joint destruction. The pathogenesis of RA is not clear, but is considered to be an immune-mediated inflammatory disorder, in which the complement system plays an important role. Although cell-derived microparticles (MPs) have been associated with inflammation and complement activation,...
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The attachment of particle-bound IgG in a nonphagocytic system stimulates formation of a microfilament-rich, organelle-poor zone in the subjacent cytoplasm of human neutrophils. The attachment site is characterized by ruffling and invagination of the neutrophil membrane. Both IgG attachment and formation of the organelle-poor zone are inhibited by the microfilament inhibitor cytochalasin-B, but...
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BACKGROUND Tumour necrosis factor (TNF) blocking agents decrease C reactive protein (CRP) levels in rheumatoid arthritis (RA). It has been shown that CRP may contribute to complement activation in RA. OBJECTIVE To assess the effect of intravenous infliximab treatment on complement activation, especially that mediated by CRP, in RA. METHODS 35 patients with active RA (28 joint count Disease ...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1982
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780250911